Auflistung Nach Schlagwort "general control non derepressible 2 kinase"

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Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells

Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2015)

Indoleamine 2,3-dioxygenase (IDO) is expressed in antigen-presenting cells and exerts immunosuppressive effects on CD4+ T cells. One mechanism is through the inhibition of aerobic glycolysis. Another prerequisite for T-cell ...
Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways

Eleftheriadis T., Pissas G., Sounidaki M., Antoniadi G., Rountas C., Liakopoulos V., Stefanidis L. (2017)

In atherosclerosis-associated pathologic entities characterized by malnutrition and inflammation, l-tryptophan (TRP) levels are low. Insulin resistance is an independent cardiovascular risk factor and induces endothelial ...